diff --git a/package.json b/package.json
index 8a5f13b..fe364d3 100644
--- a/package.json
+++ b/package.json
@@ -45,7 +45,7 @@
     "poisson-process": "^0.2.1"
   },
   "engines": {
-    "node": ">=0.10.13"
+    "node": ">=0.12.0"
   },
   "binary": {
     "module_name": "grpc_node",
diff --git a/templates/package.json.template b/templates/package.json.template
index ec44497..d6279b9 100644
--- a/templates/package.json.template
+++ b/templates/package.json.template
@@ -47,7 +47,7 @@
       "poisson-process": "^0.2.1"
     },
     "engines": {
-      "node": ">=0.10.13"
+      "node": ">=0.12.0"
     },
     "binary": {
       "module_name": "grpc_node",
diff --git a/tools/run_tests/build_artifact_node.bat b/tools/run_tests/build_artifact_node.bat
index f150bb1..84c63c2 100644
--- a/tools/run_tests/build_artifact_node.bat
+++ b/tools/run_tests/build_artifact_node.bat
@@ -27,7 +27,7 @@
 @rem (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE
 @rem OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
 
-set node_versions=0.10.41 0.12.0 1.0.0 1.1.0 2.0.0 3.0.0 4.0.0 5.0.0
+set node_versions=0.12.0 1.0.0 1.1.0 2.0.0 3.0.0 4.0.0 5.0.0
 
 set PATH=%PATH%;C:\Program Files\nodejs\;%APPDATA%\npm
 
diff --git a/tools/run_tests/build_artifact_node.sh b/tools/run_tests/build_artifact_node.sh
index 8aeec79..9a3b9bd 100755
--- a/tools/run_tests/build_artifact_node.sh
+++ b/tools/run_tests/build_artifact_node.sh
@@ -42,7 +42,7 @@
 
 npm update
 
-node_versions=( 0.10.41 0.12.0 1.0.0 1.1.0 2.0.0 3.0.0 4.0.0 5.0.0 )
+node_versions=( 0.12.0 1.0.0 1.1.0 2.0.0 3.0.0 4.0.0 5.0.0 )
 
 for version in ${node_versions[@]}
 do
diff --git a/tools/run_tests/distribtest_targets.py b/tools/run_tests/distribtest_targets.py
index fc7dd17..e426afb 100644
--- a/tools/run_tests/distribtest_targets.py
+++ b/tools/run_tests/distribtest_targets.py
@@ -233,5 +233,5 @@
             NodeDistribTest('linux', 'x64', os, version)
             for os in ('wheezy', 'jessie', 'ubuntu1204', 'ubuntu1404',
                        'ubuntu1504', 'ubuntu1510', 'ubuntu1604')
-            for version in ('0.10', '0.12', '3', '4', '5')
+            for version in ('0.12', '3', '4', '5')
           ]