diff --git a/Parser/asdl_c.py b/Parser/asdl_c.py
index 0159701..3772b12 100755
--- a/Parser/asdl_c.py
+++ b/Parser/asdl_c.py
@@ -367,6 +367,7 @@
         self.emit("obj2ast_%s(PyObject* obj, %s* out, PyArena* arena)" % (name, ctype), 0)
         self.emit("{", 0)
         self.emit("PyObject* tmp = NULL;", 1)
+        self.emit("int isinstance;", 1)
         self.emit("", 0)
 
     def sumTrailer(self, name):
@@ -386,7 +387,13 @@
     def simpleSum(self, sum, name):
         self.funcHeader(name)
         for t in sum.types:
-            self.emit("if (PyObject_IsInstance(obj, (PyObject*)%s_type)) {" % t.name, 1)
+            line = ("isinstance = PyObject_IsInstance(obj, "
+                    "(PyObject *)%s_type);")
+            self.emit(line % (t.name,), 1)
+            self.emit("if (isinstance == -1) {", 1)
+            self.emit("return 1;", 2)
+            self.emit("}", 1)
+            self.emit("if (isinstance) {", 1)
             self.emit("*out = %s;" % t.name, 2)
             self.emit("return 0;", 2)
             self.emit("}", 1)
@@ -408,7 +415,12 @@
         for a in sum.attributes:
             self.visitField(a, name, sum=sum, depth=1)
         for t in sum.types:
-            self.emit("if (PyObject_IsInstance(obj, (PyObject*)%s_type)) {" % t.name, 1)
+            line = "isinstance = PyObject_IsInstance(obj, (PyObject*)%s_type);"
+            self.emit(line % (t.name,), 1)
+            self.emit("if (isinstance == -1) {", 1)
+            self.emit("return 1;", 2)
+            self.emit("}", 1)
+            self.emit("if (isinstance) {", 1)
             for f in t.fields:
                 self.visitFieldDeclaration(f, t.name, sum=sum, depth=2)
             self.emit("", 0)
@@ -1093,11 +1105,15 @@
     PyObject *req_type[] = {(PyObject*)Module_type, (PyObject*)Expression_type,
                             (PyObject*)Interactive_type};
     char *req_name[] = {"Module", "Expression", "Interactive"};
+    int isinstance;
     assert(0 <= mode && mode <= 2);
 
     init_types();
 
-    if (!PyObject_IsInstance(ast, req_type[mode])) {
+    isinstance = PyObject_IsInstance(ast, req_type[mode]);
+    if (isinstance == -1)
+        return NULL;
+    if (!isinstance) {
         PyErr_Format(PyExc_TypeError, "expected %s node, got %.400s",
                      req_name[mode], Py_TYPE(ast)->tp_name);
         return NULL;
diff --git a/Python/Python-ast.c b/Python/Python-ast.c
index 4a999d1..bc6cca0 100644
--- a/Python/Python-ast.c
+++ b/Python/Python-ast.c
@@ -3180,13 +3180,18 @@
 obj2ast_mod(PyObject* obj, mod_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
 
         if (obj == Py_None) {
                 *out = NULL;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Module_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Module_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* body;
 
                 if (PyObject_HasAttrString(obj, "body")) {
@@ -3218,7 +3223,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Interactive_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Interactive_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* body;
 
                 if (PyObject_HasAttrString(obj, "body")) {
@@ -3250,7 +3259,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Expression_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Expression_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty body;
 
                 if (PyObject_HasAttrString(obj, "body")) {
@@ -3269,7 +3282,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Suite_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Suite_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* body;
 
                 if (PyObject_HasAttrString(obj, "body")) {
@@ -3314,6 +3331,7 @@
 obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
         int lineno;
         int col_offset;
@@ -3346,7 +3364,11 @@
                 PyErr_SetString(PyExc_TypeError, "required field \"col_offset\" missing from stmt");
                 return 1;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)FunctionDef_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)FunctionDef_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 identifier name;
                 arguments_ty args;
                 asdl_seq* body;
@@ -3431,7 +3453,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)ClassDef_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)ClassDef_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 identifier name;
                 asdl_seq* bases;
                 asdl_seq* body;
@@ -3529,7 +3555,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Return_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Return_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty value;
 
                 if (PyObject_HasAttrString(obj, "value")) {
@@ -3547,7 +3577,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Delete_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Delete_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* targets;
 
                 if (PyObject_HasAttrString(obj, "targets")) {
@@ -3579,7 +3613,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Assign_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Assign_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* targets;
                 expr_ty value;
 
@@ -3624,7 +3662,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)AugAssign_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)AugAssign_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty target;
                 operator_ty op;
                 expr_ty value;
@@ -3669,7 +3711,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Print_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Print_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty dest;
                 asdl_seq* values;
                 bool nl;
@@ -3726,7 +3772,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)For_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)For_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty target;
                 expr_ty iter;
                 asdl_seq* body;
@@ -3811,7 +3861,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)While_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)While_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty test;
                 asdl_seq* body;
                 asdl_seq* orelse;
@@ -3882,7 +3936,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)If_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)If_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty test;
                 asdl_seq* body;
                 asdl_seq* orelse;
@@ -3953,7 +4011,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)With_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)With_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty context_expr;
                 expr_ty optional_vars;
                 asdl_seq* body;
@@ -4011,7 +4073,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Raise_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Raise_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty type;
                 expr_ty inst;
                 expr_ty tback;
@@ -4053,7 +4119,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)TryExcept_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)TryExcept_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* body;
                 asdl_seq* handlers;
                 asdl_seq* orelse;
@@ -4138,7 +4208,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)TryFinally_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)TryFinally_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* body;
                 asdl_seq* finalbody;
 
@@ -4196,7 +4270,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Assert_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Assert_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty test;
                 expr_ty msg;
 
@@ -4227,7 +4305,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Import_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Import_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* names;
 
                 if (PyObject_HasAttrString(obj, "names")) {
@@ -4259,7 +4341,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)ImportFrom_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)ImportFrom_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 identifier module;
                 asdl_seq* names;
                 int level;
@@ -4317,7 +4403,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Exec_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Exec_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty body;
                 expr_ty globals;
                 expr_ty locals;
@@ -4360,7 +4450,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Global_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Global_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* names;
 
                 if (PyObject_HasAttrString(obj, "names")) {
@@ -4392,7 +4486,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Expr_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Expr_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty value;
 
                 if (PyObject_HasAttrString(obj, "value")) {
@@ -4411,19 +4509,31 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Pass_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Pass_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
 
                 *out = Pass(lineno, col_offset, arena);
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Break_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Break_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
 
                 *out = Break(lineno, col_offset, arena);
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Continue_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Continue_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
 
                 *out = Continue(lineno, col_offset, arena);
                 if (*out == NULL) goto failed;
@@ -4442,6 +4552,7 @@
 obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
         int lineno;
         int col_offset;
@@ -4474,7 +4585,11 @@
                 PyErr_SetString(PyExc_TypeError, "required field \"col_offset\" missing from expr");
                 return 1;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)BoolOp_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)BoolOp_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 boolop_ty op;
                 asdl_seq* values;
 
@@ -4519,7 +4634,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)BinOp_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)BinOp_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty left;
                 operator_ty op;
                 expr_ty right;
@@ -4564,7 +4683,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)UnaryOp_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)UnaryOp_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 unaryop_ty op;
                 expr_ty operand;
 
@@ -4596,7 +4719,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Lambda_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Lambda_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 arguments_ty args;
                 expr_ty body;
 
@@ -4628,7 +4755,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)IfExp_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)IfExp_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty test;
                 expr_ty body;
                 expr_ty orelse;
@@ -4673,7 +4804,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Dict_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Dict_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* keys;
                 asdl_seq* values;
 
@@ -4731,7 +4866,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)ListComp_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)ListComp_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty elt;
                 asdl_seq* generators;
 
@@ -4776,7 +4915,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)GeneratorExp_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)GeneratorExp_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty elt;
                 asdl_seq* generators;
 
@@ -4821,7 +4964,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Yield_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Yield_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty value;
 
                 if (PyObject_HasAttrString(obj, "value")) {
@@ -4839,7 +4986,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Compare_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Compare_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty left;
                 asdl_int_seq* ops;
                 asdl_seq* comparators;
@@ -4911,7 +5062,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Call_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Call_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty func;
                 asdl_seq* args;
                 asdl_seq* keywords;
@@ -5007,7 +5162,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Repr_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Repr_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty value;
 
                 if (PyObject_HasAttrString(obj, "value")) {
@@ -5026,7 +5185,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Num_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Num_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 object n;
 
                 if (PyObject_HasAttrString(obj, "n")) {
@@ -5045,7 +5208,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Str_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Str_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 string s;
 
                 if (PyObject_HasAttrString(obj, "s")) {
@@ -5064,7 +5231,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Attribute_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Attribute_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty value;
                 identifier attr;
                 expr_context_ty ctx;
@@ -5109,7 +5280,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Subscript_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Subscript_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty value;
                 slice_ty slice;
                 expr_context_ty ctx;
@@ -5154,7 +5329,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Name_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Name_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 identifier id;
                 expr_context_ty ctx;
 
@@ -5186,7 +5365,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)List_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)List_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* elts;
                 expr_context_ty ctx;
 
@@ -5231,7 +5414,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Tuple_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Tuple_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* elts;
                 expr_context_ty ctx;
 
@@ -5289,28 +5476,53 @@
 obj2ast_expr_context(PyObject* obj, expr_context_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
-        if (PyObject_IsInstance(obj, (PyObject*)Load_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Load_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Load;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Store_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Store_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Store;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Del_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Del_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Del;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)AugLoad_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)AugLoad_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = AugLoad;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)AugStore_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)AugStore_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = AugStore;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Param_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Param_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Param;
                 return 0;
         }
@@ -5327,19 +5539,28 @@
 obj2ast_slice(PyObject* obj, slice_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
 
         if (obj == Py_None) {
                 *out = NULL;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Ellipsis_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Ellipsis_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
 
                 *out = Ellipsis(arena);
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Slice_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Slice_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty lower;
                 expr_ty upper;
                 expr_ty step;
@@ -5381,7 +5602,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)ExtSlice_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)ExtSlice_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* dims;
 
                 if (PyObject_HasAttrString(obj, "dims")) {
@@ -5413,7 +5638,11 @@
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Index_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Index_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty value;
 
                 if (PyObject_HasAttrString(obj, "value")) {
@@ -5445,12 +5674,21 @@
 obj2ast_boolop(PyObject* obj, boolop_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
-        if (PyObject_IsInstance(obj, (PyObject*)And_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)And_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = And;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Or_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Or_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Or;
                 return 0;
         }
@@ -5467,52 +5705,101 @@
 obj2ast_operator(PyObject* obj, operator_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
-        if (PyObject_IsInstance(obj, (PyObject*)Add_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Add_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Add;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Sub_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Sub_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Sub;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Mult_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Mult_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Mult;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Div_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Div_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Div;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Mod_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Mod_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Mod;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Pow_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Pow_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Pow;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)LShift_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)LShift_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = LShift;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)RShift_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)RShift_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = RShift;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)BitOr_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)BitOr_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = BitOr;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)BitXor_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)BitXor_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = BitXor;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)BitAnd_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)BitAnd_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = BitAnd;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)FloorDiv_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)FloorDiv_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = FloorDiv;
                 return 0;
         }
@@ -5529,20 +5816,37 @@
 obj2ast_unaryop(PyObject* obj, unaryop_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
-        if (PyObject_IsInstance(obj, (PyObject*)Invert_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Invert_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Invert;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Not_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Not_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Not;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)UAdd_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)UAdd_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = UAdd;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)USub_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)USub_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = USub;
                 return 0;
         }
@@ -5559,44 +5863,85 @@
 obj2ast_cmpop(PyObject* obj, cmpop_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
-        if (PyObject_IsInstance(obj, (PyObject*)Eq_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Eq_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Eq;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)NotEq_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)NotEq_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = NotEq;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Lt_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Lt_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Lt;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)LtE_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)LtE_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = LtE;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Gt_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Gt_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Gt;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)GtE_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)GtE_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = GtE;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Is_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Is_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Is;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)IsNot_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)IsNot_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = IsNot;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)In_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)In_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = In;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)NotIn_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)NotIn_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = NotIn;
                 return 0;
         }
@@ -5677,6 +6022,7 @@
 obj2ast_excepthandler(PyObject* obj, excepthandler_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
         int lineno;
         int col_offset;
@@ -5709,7 +6055,11 @@
                 PyErr_SetString(PyExc_TypeError, "required field \"col_offset\" missing from excepthandler");
                 return 1;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)ExceptHandler_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)ExceptHandler_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty type;
                 expr_ty name;
                 asdl_seq* body;
@@ -6110,11 +6460,15 @@
     PyObject *req_type[] = {(PyObject*)Module_type, (PyObject*)Expression_type,
                             (PyObject*)Interactive_type};
     char *req_name[] = {"Module", "Expression", "Interactive"};
+    int isinstance;
     assert(0 <= mode && mode <= 2);
 
     init_types();
 
-    if (!PyObject_IsInstance(ast, req_type[mode])) {
+    isinstance = PyObject_IsInstance(ast, req_type[mode]);
+    if (isinstance == -1)
+        return NULL;
+    if (!isinstance) {
         PyErr_Format(PyExc_TypeError, "expected %s node, got %.400s",
                      req_name[mode], Py_TYPE(ast)->tp_name);
         return NULL;
diff --git a/Python/bltinmodule.c b/Python/bltinmodule.c
index 1cab40c..4b5a062 100644
--- a/Python/bltinmodule.c
+++ b/Python/bltinmodule.c
@@ -465,6 +465,7 @@
 	int mode = -1;
 	int dont_inherit = 0;
 	int supplied_flags = 0;
+	int is_ast;
 	PyCompilerFlags cf;
 	PyObject *result = NULL, *cmd, *tmp = NULL;
 	Py_ssize_t length;
@@ -504,7 +505,10 @@
 		return NULL;
 	}
 
-	if (PyAST_Check(cmd)) {
+	is_ast = PyAST_Check(cmd);
+	if (is_ast == -1)
+		return NULL;
+	if (is_ast) {
 		if (supplied_flags & PyCF_ONLY_AST) {
 			Py_INCREF(cmd);
 			result = cmd;