diff --git a/Lib/test/test_signal.py b/Lib/test/test_signal.py
index 2803785..fa06729 100644
--- a/Lib/test/test_signal.py
+++ b/Lib/test/test_signal.py
@@ -227,6 +227,13 @@
             signal.signal(7, handler)
 
 
+class WakeupFDTests(unittest.TestCase):
+
+    def test_invalid_fd(self):
+        fd = support.make_bad_fd()
+        self.assertRaises(ValueError, signal.set_wakeup_fd, fd)
+
+
 @unittest.skipIf(sys.platform == "win32", "Not valid on Windows")
 class WakeupSignalTests(unittest.TestCase):
     TIMEOUT_FULL = 10
@@ -485,8 +492,9 @@
 
 def test_main():
     test_support.run_unittest(BasicSignalTests, InterProcessSignalTests,
-                              WakeupSignalTests, SiginterruptTest,
-                              ItimerTest, WindowsSignalTests)
+                              WakeupFDTests, WakeupSignalTests,
+                              SiginterruptTest, ItimerTest,
+                              WindowsSignalTests)
 
 
 if __name__ == "__main__":
diff --git a/Misc/NEWS b/Misc/NEWS
index eb41458..f7491d1 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -189,6 +189,9 @@
 Library
 -------
 
+- Issue #16992: On Windows in signal.set_wakeup_fd, validate the file
+  descriptor argument.
+
 - Issue #15861: tkinter now correctly works with lists and tuples containing
   strings with whitespaces, backslashes or unbalanced braces.
 
diff --git a/Modules/signalmodule.c b/Modules/signalmodule.c
index f706a8f..d5d6283 100644
--- a/Modules/signalmodule.c
+++ b/Modules/signalmodule.c
@@ -407,7 +407,7 @@
         return NULL;
     }
 #endif
-    if (fd != -1 && fstat(fd, &buf) != 0) {
+    if (fd != -1 && (!_PyVerify_fd(fd) || fstat(fd, &buf) != 0)) {
         PyErr_SetString(PyExc_ValueError, "invalid fd");
         return NULL;
     }