diff --git a/Lib/distutils/msvc9compiler.py b/Lib/distutils/msvc9compiler.py
index ef89542..c84fb0b 100644
--- a/Lib/distutils/msvc9compiler.py
+++ b/Lib/distutils/msvc9compiler.py
@@ -17,6 +17,7 @@
 import os
 import subprocess
 import sys
+import re
 
 from distutils.errors import DistutilsExecError, DistutilsPlatformError, \
                              CompileError, LibError, LinkError
@@ -645,6 +646,28 @@
                 mfid = 1
             else:
                 mfid = 2
+                try:
+                    # Remove references to the Visual C runtime, so they will
+                    # fall through to the Visual C dependency of Python.exe.
+                    # This way, when installed for a restricted user (e.g.
+                    # runtimes are not in WinSxS folder, but in Python's own
+                    # folder), the runtimes do not need to be in every folder
+                    # with .pyd's.
+                    manifest_f = open(temp_manifest, "rb")
+                    manifest_buf = manifest_f.read()
+                    manifest_f.close()
+                    pattern = re.compile(
+                        r"""<assemblyIdentity.*?name=("|')Microsoft\."""\
+                        r"""VC\d{2}\.CRT("|').*?(/>|</assemblyIdentity>)""",
+                        re.DOTALL)
+                    manifest_buf = re.sub(pattern, "", manifest_buf)
+                    pattern = "<dependentAssembly>\s*</dependentAssembly>"
+                    manifest_buf = re.sub(pattern, "", manifest_buf)
+                    manifest_f = open(temp_manifest, "wb")
+                    manifest_f.write(manifest_buf)
+                    manifest_f.close()
+                except IOError:
+                    pass
             out_arg = '-outputresource:%s;%s' % (output_filename, mfid)
             try:
                 self.spawn(['mt.exe', '-nologo', '-manifest',
diff --git a/Misc/NEWS b/Misc/NEWS
index 6a216ed4..fa881c9 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -154,6 +154,9 @@
 Library
 -------
 
+- Issue #4120: Drop reference to CRT from manifest when building extensions with
+  msvc9compiler.
+
 - Issue #7333: The `posix` module gains an `initgroups()` function providing
   access to the initgroups(3) C library call on Unix systems which implement
   it.  Patch by Jean-Paul Calderone.