diff --git a/Doc/library/stdtypes.rst b/Doc/library/stdtypes.rst
index 758ee7b..64d3c32 100644
--- a/Doc/library/stdtypes.rst
+++ b/Doc/library/stdtypes.rst
@@ -1583,10 +1583,13 @@
       .. versionchanged:: 2.6
          Accepts multiple input iterables.
 
-   .. method:: difference(other)
-               set - other
+   .. method:: difference(other, ...)
+               set - other - ...
 
-      Return a new set with elements in the set that are not in *other*.
+      Return a new set with elements in the set that are not in the others.
+
+      .. versionchanged:: 2.6
+         Accepts multiple input iterables.
 
    .. method:: symmetric_difference(other)
                set ^ other
@@ -1650,10 +1653,13 @@
       .. versionchanged:: 2.6
          Accepts multiple input iterables.
 
-   .. method:: difference_update(other)
-               set -= other
+   .. method:: difference_update(other, ...)
+               set -= other | ...
 
-      Update the set, removing elements found in *other*.
+      Update the set, removing elements found in others.
+
+      .. versionchanged:: 2.6
+         Accepts multiple input iterables.
 
    .. method:: symmetric_difference_update(other)
                set ^= other
diff --git a/Lib/test/test_set.py b/Lib/test/test_set.py
index b32d953..1b01954 100644
--- a/Lib/test/test_set.py
+++ b/Lib/test/test_set.py
@@ -149,6 +149,8 @@
             self.assertEqual(self.thetype('abcba').difference(C('efgfe')), set('abc'))
             self.assertEqual(self.thetype('abcba').difference(C('ccb')), set('a'))
             self.assertEqual(self.thetype('abcba').difference(C('ef')), set('abc'))
+            self.assertEqual(self.thetype('abcba').difference(), set('abc'))
+            self.assertEqual(self.thetype('abcba').difference(C('a'), C('b')), set('c'))
 
     def test_sub(self):
         i = self.s.difference(self.otherword)
@@ -467,6 +469,18 @@
                 self.assertEqual(s.difference_update(C(p)), None)
                 self.assertEqual(s, set(q))
 
+                s = self.thetype('abcdefghih')
+                s.difference_update()
+                self.assertEqual(s, self.thetype('abcdefghih'))
+
+                s = self.thetype('abcdefghih')
+                s.difference_update(C('aba'))
+                self.assertEqual(s, self.thetype('cdefghih'))
+
+                s = self.thetype('abcdefghih')
+                s.difference_update(C('cdc'), C('aba'))
+                self.assertEqual(s, self.thetype('efghih'))
+
     def test_isub(self):
         self.s -= set(self.otherword)
         for c in (self.word + self.otherword):
diff --git a/Misc/NEWS b/Misc/NEWS
index f721122..afaf05b 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -13,7 +13,7 @@
 -----------------
 
 - Several set methods now accept multiple arguments:  update(), union(),
-  intersection() and intersection_update().
+  intersection(), intersection_update(), difference(), and difference_update().
 
 - Issue #2898: Added sys.getsizeof() to retrieve size of objects in bytes.
 
diff --git a/Objects/setobject.c b/Objects/setobject.c
index 1127680..f3eea21 100644
--- a/Objects/setobject.c
+++ b/Objects/setobject.c
@@ -1495,11 +1495,16 @@
 }
 
 static PyObject *
-set_difference_update(PySetObject *so, PyObject *other)
+set_difference_update(PySetObject *so, PyObject *args)
 {
-	if (set_difference_update_internal(so, other) != -1)
-		Py_RETURN_NONE;
-	return NULL;
+	Py_ssize_t i;
+
+	for (i=0 ; i<PyTuple_GET_SIZE(args) ; i++) {
+		PyObject *other = PyTuple_GET_ITEM(args, i);
+		if (set_difference_update_internal(so, other) == -1)
+			return NULL;
+	}
+	Py_RETURN_NONE;
 }
 
 PyDoc_STRVAR(difference_update_doc,
@@ -1557,10 +1562,34 @@
 	return result;
 }
 
+static PyObject *
+set_difference_multi(PySetObject *so, PyObject *args)
+{
+	Py_ssize_t i;
+	PyObject *result, *other;
+
+	if (PyTuple_GET_SIZE(args) == 0)
+		return set_copy(so);
+
+	other = PyTuple_GET_ITEM(args, 0);
+	result = set_difference(so, other);
+	if (result == NULL)
+		return NULL;
+
+	for (i=1 ; i<PyTuple_GET_SIZE(args) ; i++) {
+		other = PyTuple_GET_ITEM(args, i);
+		if (set_difference_update_internal((PySetObject *)result, other) == -1) {
+			Py_DECREF(result);
+			return NULL;
+		}
+	}
+	return result;
+}
+
 PyDoc_STRVAR(difference_doc,
-"Return the difference of two sets as a new set.\n\
+"Return the difference of two or more sets as a new set.\n\
 \n\
-(i.e. all elements that are in this set but not the other.)");
+(i.e. all elements that are in this set but not the others.)");
 static PyObject *
 set_sub(PySetObject *so, PyObject *other)
 {
@@ -1574,16 +1603,12 @@
 static PyObject *
 set_isub(PySetObject *so, PyObject *other)
 {
-	PyObject *result;
-
 	if (!PyAnySet_Check(other)) {
 		Py_INCREF(Py_NotImplemented);
 		return Py_NotImplemented;
 	}
-	result = set_difference_update(so, other);
-	if (result == NULL)
+	if (set_difference_update_internal(so, other) == -1)
 		return NULL;
-	Py_DECREF(result);
 	Py_INCREF(so);
 	return (PyObject *)so;
 }
@@ -1978,9 +2003,9 @@
 	 copy_doc},
 	{"discard",	(PyCFunction)set_discard,	METH_O,
 	 discard_doc},
-	{"difference",	(PyCFunction)set_difference,	METH_O,
+	{"difference",	(PyCFunction)set_difference_multi,	METH_VARARGS,
 	 difference_doc},
-	{"difference_update",	(PyCFunction)set_difference_update,	METH_O,
+	{"difference_update",	(PyCFunction)set_difference_update,	METH_VARARGS,
 	 difference_update_doc},
 	{"intersection",(PyCFunction)set_intersection_multi,	METH_VARARGS,
 	 intersection_doc},
@@ -2107,7 +2132,7 @@
 	 contains_doc},
 	{"copy",	(PyCFunction)frozenset_copy,	METH_NOARGS,
 	 copy_doc},
-	{"difference",	(PyCFunction)set_difference,	METH_O,
+	{"difference",	(PyCFunction)set_difference_multi,	METH_VARARGS,
 	 difference_doc},
 	{"intersection",(PyCFunction)set_intersection_multi,	METH_VARARGS,
 	 intersection_doc},