diff --git a/Lib/distutils/sysconfig.py b/Lib/distutils/sysconfig.py
index a3ef3f6..fbeb45f 100644
--- a/Lib/distutils/sysconfig.py
+++ b/Lib/distutils/sysconfig.py
@@ -130,7 +130,7 @@
             if get_python_version() < "2.2":
                 return prefix
             else:
-                return os.path.join(PREFIX, "Lib", "site-packages")
+                return os.path.join(prefix, "Lib", "site-packages")
     elif os.name == "mac":
         if plat_specific:
             if standard_lib:
@@ -144,9 +144,9 @@
                 return os.path.join(prefix, "Lib", "site-packages")
     elif os.name == "os2":
         if standard_lib:
-            return os.path.join(PREFIX, "Lib")
+            return os.path.join(prefix, "Lib")
         else:
-            return os.path.join(PREFIX, "Lib", "site-packages")
+            return os.path.join(prefix, "Lib", "site-packages")
     else:
         raise DistutilsPlatformError(
             "I don't know where Python installs its library "
diff --git a/Lib/distutils/tests/test_sysconfig.py b/Lib/distutils/tests/test_sysconfig.py
index af6f183..1e9dbd5 100644
--- a/Lib/distutils/tests/test_sysconfig.py
+++ b/Lib/distutils/tests/test_sysconfig.py
@@ -26,6 +26,8 @@
         # XXX doesn't work on Linux when Python was never installed before
         #self.assert_(os.path.isdir(lib_dir), lib_dir)
         # test for pythonxx.lib?
+        self.assertNotEqual(sysconfig.get_python_lib(),
+                            sysconfig.get_python_lib(prefix=TESTFN))
 
     def test_get_python_inc(self):
         inc_dir = sysconfig.get_python_inc()
diff --git a/Misc/NEWS b/Misc/NEWS
index 7a4fb9e..efedd79 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -163,6 +163,9 @@
 Library
 -------
 
+- Issue #3386: distutils.sysconfig.get_python_lib prefix argument was ignored
+  under NT and OS2. Patch by Philip Jenvey.
+
 - Issue #5128: Make compileall properly inspect bytecode to determine if needs
   to be recreated. This avoids a timing hole thanks to the old reliance on the
   ctime of the files involved.