diff --git a/Lib/lib-tk/Tkinter.py b/Lib/lib-tk/Tkinter.py
index 795cc45..cec31fd 100644
--- a/Lib/lib-tk/Tkinter.py
+++ b/Lib/lib-tk/Tkinter.py
@@ -1709,7 +1709,9 @@
         self.tk = _tkinter.create(screenName, baseName, className, interactive, wantobjects, useTk, sync, use)
         if useTk:
             self._loadtk()
-        self.readprofile(baseName, className)
+        if not sys.flags.ignore_environment:
+            # Issue #16248: Honor the -E flag to avoid code injection.
+            self.readprofile(baseName, className)
     def loadtk(self):
         if not self._tkloaded:
             self.tk.loadtk()