diff --git a/Lib/test/test_file2k.py b/Lib/test/test_file2k.py
index 0c892bd..0c633b4 100644
--- a/Lib/test/test_file2k.py
+++ b/Lib/test/test_file2k.py
@@ -2,6 +2,9 @@
 import os
 import unittest
 import itertools
+import select
+import signal
+import subprocess
 import time
 from array import array
 from weakref import proxy
@@ -602,6 +605,148 @@
         self._test_close_open_io(io_func)
 
 
+@unittest.skipUnless(os.name == 'posix', 'test requires a posix system.')
+class TestFileSignalEINTR(unittest.TestCase):
+    def _test_reading(self, data_to_write, read_and_verify_code, method_name,
+                      universal_newlines=False):
+        """Generic buffered read method test harness to verify EINTR behavior.
+
+        Also validates that Python signal handlers are run during the read.
+
+        Args:
+            data_to_write: String to write to the child process for reading
+                before sending it a signal, confirming the signal was handled,
+                writing a final newline char and closing the infile pipe.
+            read_and_verify_code: Single "line" of code to read from a file
+                object named 'infile' and validate the result.  This will be
+                executed as part of a python subprocess fed data_to_write.
+            method_name: The name of the read method being tested, for use in
+                an error message on failure.
+            universal_newlines: If True, infile will be opened in universal
+                newline mode in the child process.
+        """
+        if universal_newlines:
+            # Test the \r\n -> \n conversion while we're at it.
+            data_to_write = data_to_write.replace('\n', '\r\n')
+            infile_setup_code = 'infile = os.fdopen(sys.stdin.fileno(), "rU")'
+        else:
+            infile_setup_code = 'infile = sys.stdin'
+        # Total pipe IO in this function is smaller than the minimum posix OS
+        # pipe buffer size of 512 bytes.  No writer should block.
+        assert len(data_to_write) < 512, 'data_to_write must fit in pipe buf.'
+
+        child_code = (
+             'import os, signal, sys ;'
+             'signal.signal('
+                     'signal.SIGINT, lambda s, f: sys.stderr.write("$\\n")) ;'
+             + infile_setup_code + ' ;' +
+             'assert isinstance(infile, file) ;'
+             'sys.stderr.write("Go.\\n") ;'
+             + read_and_verify_code)
+        reader_process = subprocess.Popen(
+                [sys.executable, '-c', child_code],
+                stdin=subprocess.PIPE, stdout=subprocess.PIPE,
+                stderr=subprocess.PIPE)
+        # Wait for the signal handler to be installed.
+        go = reader_process.stderr.read(4)
+        if go != 'Go.\n':
+            reader_process.kill()
+            self.fail('Error from %s process while awaiting "Go":\n%s' % (
+                    method_name, go+reader_process.stderr.read()))
+        reader_process.stdin.write(data_to_write)
+        signals_sent = 0
+        rlist = []
+        # We don't know when the read_and_verify_code in our child is actually
+        # executing within the read system call we want to interrupt.  This
+        # loop waits for a bit before sending the first signal to increase
+        # the likelihood of that.  Implementations without correct EINTR
+        # and signal handling usually fail this test.
+        while not rlist:
+            rlist, _, _ = select.select([reader_process.stderr], (), (), 0.05)
+            reader_process.send_signal(signal.SIGINT)
+            # Give the subprocess time to handle it before we loop around and
+            # send another one.  On OSX the second signal happening close to
+            # immediately after the first was causing the subprocess to crash
+            # via the OS's default SIGINT handler.
+            time.sleep(0.1)
+            signals_sent += 1
+            if signals_sent > 200:
+                reader_process.kill()
+                self.fail("failed to handle signal during %s." % method_name)
+        # This assumes anything unexpected that writes to stderr will also
+        # write a newline.  That is true of the traceback printing code.
+        signal_line = reader_process.stderr.readline()
+        if signal_line != '$\n':
+            reader_process.kill()
+            self.fail('Error from %s process while awaiting signal:\n%s' % (
+                    method_name, signal_line+reader_process.stderr.read()))
+        # We append a newline to our input so that a readline call can
+        # end on its own before the EOF is seen.
+        stdout, stderr = reader_process.communicate(input='\n')
+        if reader_process.returncode != 0:
+            self.fail('%s() process exited rc=%d.\nSTDOUT:\n%s\nSTDERR:\n%s' % (
+                    method_name, reader_process.returncode, stdout, stderr))
+
+    def test_readline(self, universal_newlines=False):
+        """file.readline must handle signals and not lose data."""
+        self._test_reading(
+                data_to_write='hello, world!',
+                read_and_verify_code=(
+                        'line = infile.readline() ;'
+                        'expected_line = "hello, world!\\n" ;'
+                        'assert line == expected_line, ('
+                        '"read %r expected %r" % (line, expected_line))'
+                ),
+                method_name='readline',
+                universal_newlines=universal_newlines)
+
+    def test_readline_with_universal_newlines(self):
+        self.test_readline(universal_newlines=True)
+
+    def test_readlines(self, universal_newlines=False):
+        """file.readlines must handle signals and not lose data."""
+        self._test_reading(
+                data_to_write='hello\nworld!',
+                read_and_verify_code=(
+                        'lines = infile.readlines() ;'
+                        'expected_lines = ["hello\\n", "world!\\n"] ;'
+                        'assert lines == expected_lines, ('
+                        '"readlines returned wrong data.\\n" '
+                        '"got lines %r\\nexpected  %r" '
+                        '% (lines, expected_lines))'
+                ),
+                method_name='readlines',
+                universal_newlines=universal_newlines)
+
+    def test_readlines_with_universal_newlines(self):
+        self.test_readlines(universal_newlines=True)
+
+    def test_readall(self):
+        """Unbounded file.read() must handle signals and not lose data."""
+        self._test_reading(
+                data_to_write='hello, world!abcdefghijklm',
+                read_and_verify_code=(
+                        'data = infile.read() ;'
+                        'expected_data = "hello, world!abcdefghijklm\\n";'
+                        'assert data == expected_data, ('
+                        '"read %r expected %r" % (data, expected_data))'
+                ),
+                method_name='unbounded read')
+
+    def test_readinto(self):
+        """file.readinto must handle signals and not lose data."""
+        self._test_reading(
+                data_to_write='hello, world!',
+                read_and_verify_code=(
+                        'data = bytearray(50) ;'
+                        'num_read = infile.readinto(data) ;'
+                        'expected_data = "hello, world!\\n";'
+                        'assert data[:num_read] == expected_data, ('
+                        '"read %r expected %r" % (data, expected_data))'
+                ),
+                method_name='readinto')
+
+
 class StdoutTests(unittest.TestCase):
 
     def test_move_stdout_on_write(self):
@@ -678,7 +823,7 @@
     # So get rid of it no matter what.
     try:
         run_unittest(AutoFileTests, OtherFileTests, FileSubclassTests,
-            FileThreadingTests, StdoutTests)
+            FileThreadingTests, TestFileSignalEINTR, StdoutTests)
     finally:
         if os.path.exists(TESTFN):
             os.unlink(TESTFN)
diff --git a/Misc/NEWS b/Misc/NEWS
index db28db1..62968d2 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -9,6 +9,11 @@
 Core and Builtins
 -----------------
 
+- Issue #12268: File readline, readlines and read() methods no longer lose
+  data when an underlying read system call is interrupted.  IOError is no
+  longer raised due to a read system call returning EINTR from within these
+  methods.
+
 - Issue #10053: Don't close FDs when FileIO.__init__ fails. Loosely based on
   the work by Hirokazu Yamamoto.
 
diff --git a/Objects/fileobject.c b/Objects/fileobject.c
index 1d8142e..561ec21 100644
--- a/Objects/fileobject.c
+++ b/Objects/fileobject.c
@@ -1080,12 +1080,23 @@
         return NULL;
     bytesread = 0;
     for (;;) {
+        int interrupted;
         FILE_BEGIN_ALLOW_THREADS(f)
         errno = 0;
         chunksize = Py_UniversalNewlineFread(BUF(v) + bytesread,
                   buffersize - bytesread, f->f_fp, (PyObject *)f);
+        interrupted = ferror(f->f_fp) && errno == EINTR;
         FILE_END_ALLOW_THREADS(f)
+        if (interrupted) {
+            clearerr(f->f_fp);
+            if (PyErr_CheckSignals()) {
+                Py_DECREF(v);
+                return NULL;
+            }
+        }
         if (chunksize == 0) {
+            if (interrupted)
+                continue;
             if (!ferror(f->f_fp))
                 break;
             clearerr(f->f_fp);
@@ -1100,7 +1111,7 @@
             return NULL;
         }
         bytesread += chunksize;
-        if (bytesread < buffersize) {
+        if (bytesread < buffersize && !interrupted) {
             clearerr(f->f_fp);
             break;
         }
@@ -1141,12 +1152,23 @@
     ntodo = pbuf.len;
     ndone = 0;
     while (ntodo > 0) {
+        int interrupted;
         FILE_BEGIN_ALLOW_THREADS(f)
         errno = 0;
         nnow = Py_UniversalNewlineFread(ptr+ndone, ntodo, f->f_fp,
                                         (PyObject *)f);
+        interrupted = ferror(f->f_fp) && errno == EINTR;
         FILE_END_ALLOW_THREADS(f)
+        if (interrupted) {
+            clearerr(f->f_fp);
+            if (PyErr_CheckSignals()) {
+                PyBuffer_Release(&pbuf);
+                return NULL;
+            }
+        }
         if (nnow == 0) {
+            if (interrupted)
+                continue;
             if (!ferror(f->f_fp))
                 break;
             PyErr_SetFromErrno(PyExc_IOError);
@@ -1434,8 +1456,25 @@
                 *buf++ = c;
                 if (c == '\n') break;
             }
-            if ( c == EOF && skipnextlf )
-                newlinetypes |= NEWLINE_CR;
+            if (c == EOF) {
+                if (ferror(fp) && errno == EINTR) {
+                    FUNLOCKFILE(fp);
+                    FILE_ABORT_ALLOW_THREADS(f)
+                    f->f_newlinetypes = newlinetypes;
+                    f->f_skipnextlf = skipnextlf;
+
+                    if (PyErr_CheckSignals()) {
+                        Py_DECREF(v);
+                        return NULL;
+                    }
+                    /* We executed Python signal handlers and got no exception.
+                     * Now back to reading the line where we left off. */
+                    clearerr(fp);
+                    continue;
+                }
+                if (skipnextlf)
+                    newlinetypes |= NEWLINE_CR;
+            }
         } else /* If not universal newlines use the normal loop */
         while ((c = GETC(fp)) != EOF &&
                (*buf++ = c) != '\n' &&
@@ -1449,6 +1488,16 @@
             break;
         if (c == EOF) {
             if (ferror(fp)) {
+                if (errno == EINTR) {
+                    if (PyErr_CheckSignals()) {
+                        Py_DECREF(v);
+                        return NULL;
+                    }
+                    /* We executed Python signal handlers and got no exception.
+                     * Now back to reading the line where we left off. */
+                    clearerr(fp);
+                    continue;
+                }
                 PyErr_SetFromErrno(PyExc_IOError);
                 clearerr(fp);
                 Py_DECREF(v);
@@ -1624,7 +1673,7 @@
     size_t totalread = 0;
     char *p, *q, *end;
     int err;
-    int shortread = 0;
+    int shortread = 0;  /* bool, did the previous read come up short? */
 
     if (f->f_fp == NULL)
         return err_closed();
@@ -1654,6 +1703,14 @@
             sizehint = 0;
             if (!ferror(f->f_fp))
                 break;
+            if (errno == EINTR) {
+                if (PyErr_CheckSignals()) {
+                    goto error;
+                }
+                clearerr(f->f_fp);
+                shortread = 0;
+                continue;
+            }
             PyErr_SetFromErrno(PyExc_IOError);
             clearerr(f->f_fp);
             goto error;