diff --git a/setup.py b/setup.py
index 7cb1141..d218722 100644
--- a/setup.py
+++ b/setup.py
@@ -532,8 +532,9 @@
                     for directory in reversed(options.dirs):
                         add_dir_to_list(dir_list, directory)
 
-        if os.path.normpath(sys.base_prefix) != '/usr' \
-                and not sysconfig.get_config_var('PYTHONFRAMEWORK'):
+        if (not cross_compiling and
+                os.path.normpath(sys.base_prefix) != '/usr' and
+                not sysconfig.get_config_var('PYTHONFRAMEWORK')):
             # OSX note: Don't add LIBDIR and INCLUDEDIR to building a framework
             # (PYTHONFRAMEWORK is set) to avoid # linking problems when
             # building a framework with different architectures than