diff --git a/Modules/_dbmmodule.c b/Modules/_dbmmodule.c
index 327b873..1ce85f5 100644
--- a/Modules/_dbmmodule.c
+++ b/Modules/_dbmmodule.c
@@ -14,11 +14,7 @@
  */
 #if defined(HAVE_NDBM_H)
 #include <ndbm.h>
-#if defined(PYOS_OS2) && !defined(PYCC_GCC)
-static char *which_dbm = "ndbm";
-#else
 static char *which_dbm = "GNU gdbm";  /* EMX port of GDBM */
-#endif
 #elif defined(HAVE_GDBM_NDBM_H)
 #include <gdbm/ndbm.h>
 static char *which_dbm = "GNU gdbm";
diff --git a/Modules/_lsprof.c b/Modules/_lsprof.c
index b0a226b..5657f2f 100644
--- a/Modules/_lsprof.c
+++ b/Modules/_lsprof.c
@@ -36,12 +36,8 @@
 #error "This module requires gettimeofday() on non-Windows platforms!"
 #endif
 
-#if (defined(PYOS_OS2) && defined(PYCC_GCC))
-#include <sys/time.h>
-#else
 #include <sys/resource.h>
 #include <sys/times.h>
-#endif
 
 static PY_LONG_LONG
 hpTimer(void)
diff --git a/Modules/faulthandler.c b/Modules/faulthandler.c
index 7e363f0..b0df93c 100644
--- a/Modules/faulthandler.c
+++ b/Modules/faulthandler.c
@@ -79,9 +79,6 @@
 static user_signal_t *user_signals;
 
 /* the following macros come from Python: Modules/signalmodule.c */
-#if defined(PYOS_OS2) && !defined(PYCC_GCC)
-#define NSIG 12
-#endif
 #ifndef NSIG
 # if defined(_NSIG)
 #  define NSIG _NSIG            /* For BSD/SysV */
diff --git a/Modules/fcntlmodule.c b/Modules/fcntlmodule.c
index 6b7e3fc..5509026 100644
--- a/Modules/fcntlmodule.c
+++ b/Modules/fcntlmodule.c
@@ -325,11 +325,6 @@
                           &lenobj, &startobj, &whence))
         return NULL;
 
-#if defined(PYOS_OS2) && defined(PYCC_GCC)
-    PyErr_SetString(PyExc_NotImplementedError,
-                    "lockf not supported on OS/2 (EMX)");
-    return NULL;
-#else
 #ifndef LOCK_SH
 #define LOCK_SH         1       /* shared lock */
 #define LOCK_EX         2       /* exclusive lock */
@@ -383,7 +378,6 @@
     }
     Py_INCREF(Py_None);
     return Py_None;
-#endif  /* defined(PYOS_OS2) && defined(PYCC_GCC) */
 }
 
 PyDoc_STRVAR(lockf_doc,
diff --git a/Modules/pwdmodule.c b/Modules/pwdmodule.c
index 1e0903a..d1045af 100644
--- a/Modules/pwdmodule.c
+++ b/Modules/pwdmodule.c
@@ -160,12 +160,8 @@
     struct passwd *p;
     if ((d = PyList_New(0)) == NULL)
         return NULL;
-#if defined(PYOS_OS2) && defined(PYCC_GCC)
-    if ((p = getpwuid(0)) != NULL) {
-#else
     setpwent();
     while ((p = getpwent()) != NULL) {
-#endif
         PyObject *v = mkpwent(p);
         if (v == NULL || PyList_Append(d, v) != 0) {
             Py_XDECREF(v);
diff --git a/Modules/readline.c b/Modules/readline.c
index a710652..0d99dc9 100644
--- a/Modules/readline.c
+++ b/Modules/readline.c
@@ -901,10 +901,6 @@
     using_history();
 
     rl_readline_name = "python";
-#if defined(PYOS_OS2) && defined(PYCC_GCC)
-    /* Allow $if term= in .inputrc to work */
-    rl_terminal_name = getenv("TERM");
-#endif
     /* Force rebind of TAB to insert-tab */
     rl_bind_key('\t', rl_insert);
     /* Bind both ESC-TAB and ESC-ESC to the completion function */
diff --git a/Modules/selectmodule.c b/Modules/selectmodule.c
index 7cec49b..9128ea3 100644
--- a/Modules/selectmodule.c
+++ b/Modules/selectmodule.c
@@ -47,11 +47,6 @@
 #include <sys/types.h>
 #endif
 
-#if defined(PYOS_OS2) && !defined(PYCC_GCC)
-#include <sys/time.h>
-#include <utils.h>
-#endif
-
 #ifdef MS_WINDOWS
 #  define WIN32_LEAN_AND_MEAN
 #  include <winsock.h>
diff --git a/Modules/signalmodule.c b/Modules/signalmodule.c
index 2eb7f29..f7ce48c 100644
--- a/Modules/signalmodule.c
+++ b/Modules/signalmodule.c
@@ -34,11 +34,6 @@
 #define SIG_ERR ((PyOS_sighandler_t)(-1))
 #endif
 
-#if defined(PYOS_OS2) && !defined(PYCC_GCC)
-#define NSIG 12
-#include <process.h>
-#endif
-
 #ifndef NSIG
 # if defined(_NSIG)
 #  define NSIG _NSIG            /* For BSD/SysV */
diff --git a/Modules/socketmodule.c b/Modules/socketmodule.c
index d8c81fe..1c3396f 100644
--- a/Modules/socketmodule.c
+++ b/Modules/socketmodule.c
@@ -223,13 +223,6 @@
 #endif
 
 
-#if defined(PYOS_OS2)
-# define  INCL_DOS
-# define  INCL_DOSERRORS
-# define  INCL_NOPMAPI
-# include <os2.h>
-#endif
-
 #if defined(__sgi) && _COMPILER_VERSION>700 && !_SGIAPI
 /* make sure that the reentrant (gethostbyaddr_r etc)
    functions are declared correctly if compiling with
@@ -286,12 +279,7 @@
 # include <unistd.h>
 
 /* Headers needed for inet_ntoa() and inet_addr() */
-# if defined(PYOS_OS2) && defined(PYCC_VACPP)
-#  include <netdb.h>
-typedef size_t socklen_t;
-# else
 #   include <arpa/inet.h>
-# endif
 
 #  include <fcntl.h>
 
@@ -395,11 +383,6 @@
 #define snprintf _snprintf
 #endif
 
-#if defined(PYOS_OS2) && !defined(PYCC_GCC)
-#define SOCKETCLOSE soclose
-#define NO_DUP /* Sockets are Not Actual File Handles under OS/2 */
-#endif
-
 #ifndef SOCKETCLOSE
 #define SOCKETCLOSE close
 #endif
@@ -534,42 +517,6 @@
         return PyErr_SetExcFromWindowsErr(PyExc_OSError, err_no);
 #endif
 
-#if defined(PYOS_OS2) && !defined(PYCC_GCC)
-    if (sock_errno() != NO_ERROR) {
-        APIRET rc;
-        ULONG  msglen;
-        char outbuf[100];
-        int myerrorcode = sock_errno();
-
-        /* Retrieve socket-related error message from MPTN.MSG file */
-        rc = DosGetMessage(NULL, 0, outbuf, sizeof(outbuf),
-                           myerrorcode - SOCBASEERR + 26,
-                           "mptn.msg",
-                           &msglen);
-        if (rc == NO_ERROR) {
-            PyObject *v;
-
-            /* OS/2 doesn't guarantee a terminator */
-            outbuf[msglen] = '\0';
-            if (strlen(outbuf) > 0) {
-                /* If non-empty msg, trim CRLF */
-                char *lastc = &outbuf[ strlen(outbuf)-1 ];
-                while (lastc > outbuf &&
-                       isspace(Py_CHARMASK(*lastc))) {
-                    /* Trim trailing whitespace (CRLF) */
-                    *lastc-- = '\0';
-                }
-            }
-            v = Py_BuildValue("(is)", myerrorcode, outbuf);
-            if (v != NULL) {
-                PyErr_SetObject(PyExc_OSError, v);
-                Py_DECREF(v);
-            }
-            return NULL;
-        }
-    }
-#endif
-
     return PyErr_SetFromErrno(PyExc_OSError);
 }
 
@@ -658,20 +605,17 @@
 
     Py_BEGIN_ALLOW_THREADS
 #ifndef MS_WINDOWS
-#if defined(PYOS_OS2) && !defined(PYCC_GCC)
-    block = !block;
-    ioctl(s->sock_fd, FIONBIO, (caddr_t)&block, sizeof(block));
-#elif defined(__VMS)
+#if defined(__VMS)
     block = !block;
     ioctl(s->sock_fd, FIONBIO, (unsigned int *)&block);
-#else  /* !PYOS_OS2 && !__VMS */
+#else  /* !__VMS */
     delay_flag = fcntl(s->sock_fd, F_GETFL, 0);
     if (block)
         delay_flag &= (~O_NONBLOCK);
     else
         delay_flag |= O_NONBLOCK;
     fcntl(s->sock_fd, F_SETFL, delay_flag);
-#endif /* !PYOS_OS2 */
+#endif /* !__VMS */
 #else /* MS_WINDOWS */
     block = !block;
     ioctlsocket(s->sock_fd, FIONBIO, (u_long*)&block);
@@ -1329,11 +1273,7 @@
         }
         addr->sun_family = s->sock_family;
         memcpy(addr->sun_path, path, len);
-#if defined(PYOS_OS2)
-        *len_ret = sizeof(*addr);
-#else
         *len_ret = len + offsetof(struct sockaddr_un, sun_path);
-#endif
         retval = 1;
     unix_out:
         Py_DECREF(args);
@@ -2820,13 +2760,8 @@
     timeout = internal_select_ex(s, 0, interval);
     if (!timeout) {
 #ifndef MS_WINDOWS
-#if defined(PYOS_OS2) && !defined(PYCC_GCC)
-        n = recvfrom(s->sock_fd, cbuf, len, flags,
-                     SAS2SA(&addrbuf), &addrlen);
-#else
         n = recvfrom(s->sock_fd, cbuf, len, flags,
                      (void *) &addrbuf, &addrlen);
-#endif
 #else
         n = recvfrom(s->sock_fd, cbuf, len, flags,
                      SAS2SA(&addrbuf), &addrlen);
@@ -5509,32 +5444,6 @@
 #endif /* MS_WINDOWS */
 
 
-#ifdef PYOS_OS2
-#define OS_INIT_DEFINED
-
-/* Additional initialization for OS/2 */
-
-static int
-os_init(void)
-{
-#ifndef PYCC_GCC
-    int rc = sock_init();
-
-    if (rc == 0) {
-        return 1; /* Success */
-    }
-
-    PyErr_Format(PyExc_ImportError, "OS/2 TCP/IP Error# %d", sock_errno());
-
-    return 0;  /* Failure */
-#else
-    /* No need to initialize sockets with GCC/EMX */
-    return 1; /* Success */
-#endif
-}
-
-#endif /* PYOS_OS2 */
-
 
 #ifndef OS_INIT_DEFINED
 static int
diff --git a/Modules/socketmodule.h b/Modules/socketmodule.h
index 0435878..48e0fd4 100644
--- a/Modules/socketmodule.h
+++ b/Modules/socketmodule.h
@@ -8,7 +8,7 @@
 #   include <sys/socket.h>
 # endif
 # include <netinet/in.h>
-# if !(defined(__CYGWIN__) || (defined(PYOS_OS2) && defined(PYCC_VACPP)))
+# if !defined(__CYGWIN__)
 #  include <netinet/tcp.h>
 # endif
 
diff --git a/Modules/timemodule.c b/Modules/timemodule.c
index 3b1f075..8a81c8c 100644
--- a/Modules/timemodule.c
+++ b/Modules/timemodule.c
@@ -37,16 +37,6 @@
 #endif /* MS_WINDOWS */
 #endif /* !__WATCOMC__ || __QNX__ */
 
-#if defined(PYOS_OS2)
-#define INCL_DOS
-#define INCL_ERRORS
-#include <os2.h>
-#endif
-
-#if defined(PYCC_VACPP)
-#include <sys/time.h>
-#endif
-
 #if defined(__APPLE__)
 #include <mach/mach_time.h>
 #endif
@@ -1284,19 +1274,11 @@
 #if defined(HAVE_TZNAME) && !defined(__GLIBC__) && !defined(__CYGWIN__)
     PyObject *otz0, *otz1;
     tzset();
-#ifdef PYOS_OS2
-    PyModule_AddIntConstant(m, "timezone", _timezone);
-#else /* !PYOS_OS2 */
     PyModule_AddIntConstant(m, "timezone", timezone);
-#endif /* PYOS_OS2 */
 #ifdef HAVE_ALTZONE
     PyModule_AddIntConstant(m, "altzone", altzone);
 #else
-#ifdef PYOS_OS2
-    PyModule_AddIntConstant(m, "altzone", _timezone-3600);
-#else /* !PYOS_OS2 */
     PyModule_AddIntConstant(m, "altzone", timezone-3600);
-#endif /* PYOS_OS2 */
 #endif
     PyModule_AddIntConstant(m, "daylight", daylight);
     otz0 = PyUnicode_DecodeLocale(tzname[0], "surrogateescape");
@@ -1602,15 +1584,6 @@
         }
         Py_END_ALLOW_THREADS
     }
-#elif defined(PYOS_OS2)
-    /* This Sleep *IS* Interruptable by Exceptions */
-    Py_BEGIN_ALLOW_THREADS
-    if (DosSleep(secs * 1000) != NO_ERROR) {
-        Py_BLOCK_THREADS
-        PyErr_SetFromErrno(PyExc_IOError);
-        return -1;
-    }
-    Py_END_ALLOW_THREADS
 #else
     /* XXX Can't interrupt this sleep */
     Py_BEGIN_ALLOW_THREADS