diff --git a/Modules/_ssl.c b/Modules/_ssl.c
index ed6b7a8..52695fe 100644
--- a/Modules/_ssl.c
+++ b/Modules/_ssl.c
@@ -157,21 +157,26 @@
 #endif
 
 #ifdef TLSEXT_TYPE_application_layer_protocol_negotiation
-# define HAVE_ALPN
+# define HAVE_ALPN 1
+#else
+# define HAVE_ALPN 0
 #endif
 
 /* We cannot rely on OPENSSL_NO_NEXTPROTONEG because LibreSSL 2.6.1 dropped
  * NPN support but did not set OPENSSL_NO_NEXTPROTONEG for compatibility
  * reasons. The check for TLSEXT_TYPE_next_proto_neg works with
  * OpenSSL 1.0.1+ and LibreSSL.
+ * OpenSSL 1.1.1-pre1 dropped NPN but still has TLSEXT_TYPE_next_proto_neg.
  */
 #ifdef OPENSSL_NO_NEXTPROTONEG
-#  define HAVE_NPN 0
+# define HAVE_NPN 0
+#elif (OPENSSL_VERSION_NUMBER >= 0x10101000L) && !defined(LIBRESSL_VERSION_NUMBER)
+# define HAVE_NPN 0
 #elif defined(TLSEXT_TYPE_next_proto_neg)
-#  define HAVE_NPN 1
+# define HAVE_NPN 1
 #else
-#  define HAVE_NPN 0
-# endif
+# define HAVE_NPN 0
+#endif
 
 #ifndef INVALID_SOCKET /* MS defines this */
 #define INVALID_SOCKET (-1)
@@ -341,11 +346,11 @@
 typedef struct {
     PyObject_HEAD
     SSL_CTX *ctx;
-#ifdef HAVE_NPN
+#if HAVE_NPN
     unsigned char *npn_protocols;
     int npn_protocols_len;
 #endif
-#ifdef HAVE_ALPN
+#if HAVE_ALPN
     unsigned char *alpn_protocols;
     unsigned int alpn_protocols_len;
 #endif
@@ -1922,7 +1927,7 @@
     return PyUnicode_FromString(version);
 }
 
-#ifdef HAVE_NPN
+#if HAVE_NPN
 /*[clinic input]
 _ssl._SSLSocket.selected_npn_protocol
 [clinic start generated code]*/
@@ -1943,7 +1948,7 @@
 }
 #endif
 
-#ifdef HAVE_ALPN
+#if HAVE_ALPN
 /*[clinic input]
 _ssl._SSLSocket.selected_alpn_protocol
 [clinic start generated code]*/
@@ -2887,10 +2892,10 @@
     self->ctx = ctx;
     self->hostflags = X509_CHECK_FLAG_NO_PARTIAL_WILDCARDS;
     self->protocol = proto_version;
-#ifdef HAVE_NPN
+#if HAVE_NPN
     self->npn_protocols = NULL;
 #endif
-#ifdef HAVE_ALPN
+#if HAVE_ALPN
     self->alpn_protocols = NULL;
 #endif
 #ifndef OPENSSL_NO_TLSEXT
@@ -3026,10 +3031,10 @@
     PyObject_GC_UnTrack(self);
     context_clear(self);
     SSL_CTX_free(self->ctx);
-#ifdef HAVE_NPN
+#if HAVE_NPN
     PyMem_FREE(self->npn_protocols);
 #endif
-#ifdef HAVE_ALPN
+#if HAVE_ALPN
     PyMem_FREE(self->alpn_protocols);
 #endif
     Py_TYPE(self)->tp_free(self);
@@ -3104,7 +3109,7 @@
 #endif
 
 
-#if defined(HAVE_NPN) || defined(HAVE_ALPN)
+#if HAVE_NPN || HAVE_ALPN
 static int
 do_protocol_selection(int alpn, unsigned char **out, unsigned char *outlen,
                       const unsigned char *server_protocols, unsigned int server_protocols_len,
@@ -3130,7 +3135,7 @@
 }
 #endif
 
-#ifdef HAVE_NPN
+#if HAVE_NPN
 /* this callback gets passed to SSL_CTX_set_next_protos_advertise_cb */
 static int
 _advertiseNPN_cb(SSL *s,
@@ -3173,7 +3178,7 @@
                                          Py_buffer *protos)
 /*[clinic end generated code: output=72b002c3324390c6 input=319fcb66abf95bd7]*/
 {
-#ifdef HAVE_NPN
+#if HAVE_NPN
     PyMem_Free(self->npn_protocols);
     self->npn_protocols = PyMem_Malloc(protos->len);
     if (self->npn_protocols == NULL)
@@ -3198,7 +3203,7 @@
 #endif
 }
 
-#ifdef HAVE_ALPN
+#if HAVE_ALPN
 static int
 _selectALPN_cb(SSL *s,
               const unsigned char **out, unsigned char *outlen,
@@ -3223,7 +3228,7 @@
                                           Py_buffer *protos)
 /*[clinic end generated code: output=87599a7f76651a9b input=9bba964595d519be]*/
 {
-#ifdef HAVE_ALPN
+#if HAVE_ALPN
     if ((size_t)protos->len > UINT_MAX) {
         PyErr_Format(PyExc_OverflowError,
             "protocols longer than %d bytes", UINT_MAX);
@@ -5718,7 +5723,7 @@
     Py_INCREF(r);
     PyModule_AddObject(m, "HAS_ECDH", r);
 
-#ifdef HAVE_NPN
+#if HAVE_NPN
     r = Py_True;
 #else
     r = Py_False;
@@ -5726,7 +5731,7 @@
     Py_INCREF(r);
     PyModule_AddObject(m, "HAS_NPN", r);
 
-#ifdef HAVE_ALPN
+#if HAVE_ALPN
     r = Py_True;
 #else
     r = Py_False;
diff --git a/Modules/clinic/_ssl.c.h b/Modules/clinic/_ssl.c.h
index 1ee1bfb..5ba34ec 100644
--- a/Modules/clinic/_ssl.c.h
+++ b/Modules/clinic/_ssl.c.h
@@ -132,7 +132,7 @@
     return _ssl__SSLSocket_version_impl(self);
 }
 
-#if defined(HAVE_NPN)
+#if (HAVE_NPN)
 
 PyDoc_STRVAR(_ssl__SSLSocket_selected_npn_protocol__doc__,
 "selected_npn_protocol($self, /)\n"
@@ -151,9 +151,9 @@
     return _ssl__SSLSocket_selected_npn_protocol_impl(self);
 }
 
-#endif /* defined(HAVE_NPN) */
+#endif /* (HAVE_NPN) */
 
-#if defined(HAVE_ALPN)
+#if (HAVE_ALPN)
 
 PyDoc_STRVAR(_ssl__SSLSocket_selected_alpn_protocol__doc__,
 "selected_alpn_protocol($self, /)\n"
@@ -172,7 +172,7 @@
     return _ssl__SSLSocket_selected_alpn_protocol_impl(self);
 }
 
-#endif /* defined(HAVE_ALPN) */
+#endif /* (HAVE_ALPN) */
 
 PyDoc_STRVAR(_ssl__SSLSocket_compression__doc__,
 "compression($self, /)\n"
@@ -1175,4 +1175,4 @@
 #ifndef _SSL_ENUM_CRLS_METHODDEF
     #define _SSL_ENUM_CRLS_METHODDEF
 #endif /* !defined(_SSL_ENUM_CRLS_METHODDEF) */
-/*[clinic end generated code: output=a00fef6a470cfc2c input=a9049054013a1b77]*/
+/*[clinic end generated code: output=e2417fee28666f7c input=a9049054013a1b77]*/