diff --git a/Lib/test/test_typing.py b/Lib/test/test_typing.py
index 8d6262b..3a0edb9 100644
--- a/Lib/test/test_typing.py
+++ b/Lib/test/test_typing.py
@@ -3626,6 +3626,13 @@
         return 'no chance for this as well'
 """)
 
+    def test_multiple_inheritance(self):
+        class A:
+            pass
+        with self.assertRaises(TypeError):
+            class X(NamedTuple, A):
+                x: int
+
     def test_namedtuple_keyword_usage(self):
         LocalEmployee = NamedTuple("LocalEmployee", name=str, age=int)
         nick = LocalEmployee('Nick', 25)
diff --git a/Lib/typing.py b/Lib/typing.py
index 5351883..99355d0 100644
--- a/Lib/typing.py
+++ b/Lib/typing.py
@@ -1728,6 +1728,9 @@
     def __new__(cls, typename, bases, ns):
         if ns.get('_root', False):
             return super().__new__(cls, typename, bases, ns)
+        if len(bases) > 1:
+            raise TypeError("Multiple inheritance with NamedTuple is not supported")
+        assert bases[0] is NamedTuple
         types = ns.get('__annotations__', {})
         nm_tpl = _make_nmtuple(typename, types.items())
         defaults = []