diff --git a/Lib/_osx_support.py b/Lib/_osx_support.py
index e37852e..db6674e 100644
--- a/Lib/_osx_support.py
+++ b/Lib/_osx_support.py
@@ -17,7 +17,7 @@
 _UNIVERSAL_CONFIG_VARS = ('CFLAGS', 'LDFLAGS', 'CPPFLAGS', 'BASECFLAGS',
                             'BLDSHARED', 'LDSHARED', 'CC', 'CXX',
                             'PY_CFLAGS', 'PY_LDFLAGS', 'PY_CPPFLAGS',
-                            'PY_CORE_CFLAGS')
+                            'PY_CORE_CFLAGS', 'PY_CORE_LDFLAGS')
 
 # configuration variables that may contain compiler calls
 _COMPILER_CONFIG_VARS = ('BLDSHARED', 'LDSHARED', 'CC', 'CXX')
diff --git a/Lib/test/pythoninfo.py b/Lib/test/pythoninfo.py
index 81fca10..26bcf5f 100644
--- a/Lib/test/pythoninfo.py
+++ b/Lib/test/pythoninfo.py
@@ -411,7 +411,10 @@
         'OPT',
         'PY_CFLAGS',
         'PY_CFLAGS_NODIST',
+        'PY_CORE_LDFLAGS',
         'PY_LDFLAGS',
+        'PY_LDFLAGS_NODIST',
+        'PY_STDMODULE_CFLAGS',
         'Py_DEBUG',
         'Py_ENABLE_SHARED',
         'SHELL',
diff --git a/Lib/test/test__osx_support.py b/Lib/test/test__osx_support.py
index bcba8ca..388a2b1 100644
--- a/Lib/test/test__osx_support.py
+++ b/Lib/test/test__osx_support.py
@@ -24,7 +24,7 @@
         for cv in ('CFLAGS', 'LDFLAGS', 'CPPFLAGS',
                             'BASECFLAGS', 'BLDSHARED', 'LDSHARED', 'CC',
                             'CXX', 'PY_CFLAGS', 'PY_LDFLAGS', 'PY_CPPFLAGS',
-                            'PY_CORE_CFLAGS'):
+                            'PY_CORE_CFLAGS', 'PY_CORE_LDFLAGS'):
             if cv in self.env:
                 self.env.unset(cv)
 
diff --git a/Makefile.pre.in b/Makefile.pre.in
index 9c790f1..518602b 100644
--- a/Makefile.pre.in
+++ b/Makefile.pre.in
@@ -84,6 +84,10 @@
 # Use it when a compiler flag should _not_ be part of the distutils CFLAGS
 # once Python is installed (Issue #21121).
 CONFIGURE_CFLAGS_NODIST=@CFLAGS_NODIST@
+# LDFLAGS_NODIST is used in the same manner as CFLAGS_NODIST.
+# Use it when a linker flag should _not_ be part of the distutils LDFLAGS
+# once Python is installed (bpo-35257)
+CONFIGURE_LDFLAGS_NODIST=@LDFLAGS_NODIST@
 CONFIGURE_CPPFLAGS=	@CPPFLAGS@
 CONFIGURE_LDFLAGS=	@LDFLAGS@
 # Avoid assigning CFLAGS, LDFLAGS, etc. so users can use them on the
@@ -96,6 +100,7 @@
 # environment variables
 PY_CPPFLAGS=	$(BASECPPFLAGS) -I. -I$(srcdir)/Include $(CONFIGURE_CPPFLAGS) $(CPPFLAGS)
 PY_LDFLAGS=	$(CONFIGURE_LDFLAGS) $(LDFLAGS)
+PY_LDFLAGS_NODIST=$(CONFIGURE_LDFLAGS_NODIST) $(LDFLAGS_NODIST)
 NO_AS_NEEDED=	@NO_AS_NEEDED@
 SGI_ABI=	@SGI_ABI@
 CCSHARED=	@CCSHARED@
@@ -107,6 +112,8 @@
 PY_STDMODULE_CFLAGS= $(PY_CFLAGS) $(PY_CFLAGS_NODIST) $(PY_CPPFLAGS) $(CFLAGSFORSHARED)
 PY_BUILTIN_MODULE_CFLAGS= $(PY_STDMODULE_CFLAGS) -DPy_BUILD_CORE_BUILTIN
 PY_CORE_CFLAGS=	$(PY_STDMODULE_CFLAGS) -DPy_BUILD_CORE
+# Linker flags used for building the interpreter object files
+PY_CORE_LDFLAGS=$(PY_LDFLAGS) $(PY_LDFLAGS_NODIST)
 # Strict or non-strict aliasing flags used to compile dtoa.c, see above
 CFLAGS_ALIASING=@CFLAGS_ALIASING@
 
@@ -146,7 +153,7 @@
 SHLIB_SUFFIX=	@SHLIB_SUFFIX@
 EXT_SUFFIX=	@EXT_SUFFIX@
 LDSHARED=	@LDSHARED@ $(PY_LDFLAGS)
-BLDSHARED=	@BLDSHARED@ $(PY_LDFLAGS)
+BLDSHARED=	@BLDSHARED@ $(PY_LDFLAGS_NODIST)
 LDCXXSHARED=	@LDCXXSHARED@
 DESTSHARED=	$(BINLIBDEST)/lib-dynload
 
@@ -496,7 +503,7 @@
 	touch $@
 
 build_all_generate_profile:
-	$(MAKE) @DEF_MAKE_RULE@ CFLAGS_NODIST="$(CFLAGS_NODIST) $(PGO_PROF_GEN_FLAG)" LDFLAGS="$(LDFLAGS) $(PGO_PROF_GEN_FLAG)" LIBS="$(LIBS)"
+	$(MAKE) @DEF_MAKE_RULE@ CFLAGS_NODIST="$(CFLAGS_NODIST) $(PGO_PROF_GEN_FLAG)" LDFLAGS_NODIST="$(LDFLAGS_NODIST) $(PGO_PROF_GEN_FLAG)" LIBS="$(LIBS)"
 
 run_profile_task:
 	@ # FIXME: can't run for a cross build
@@ -510,7 +517,7 @@
 profile-opt: profile-run-stamp
 	@echo "Rebuilding with profile guided optimizations:"
 	-rm -f profile-clean-stamp
-	$(MAKE) @DEF_MAKE_RULE@ CFLAGS_NODIST="$(CFLAGS_NODIST) $(PGO_PROF_USE_FLAG)" LDFLAGS="$(LDFLAGS)"
+	$(MAKE) @DEF_MAKE_RULE@ CFLAGS_NODIST="$(CFLAGS_NODIST) $(PGO_PROF_USE_FLAG)" LDFLAGS_NODIST="$(LDFLAGS_NODIST)"
 
 # Compile and run with gcov
 .PHONY=coverage coverage-lcov coverage-report
@@ -567,7 +574,7 @@
 
 # Build the interpreter
 $(BUILDPYTHON):	Programs/python.o $(LIBRARY) $(LDLIBRARY) $(PY3LIBRARY)
-	$(LINKCC) $(PY_LDFLAGS) $(LINKFORSHARED) -o $@ Programs/python.o $(BLDLIBRARY) $(LIBS) $(MODLIBS) $(SYSLIBS)
+	$(LINKCC) $(PY_CORE_LDFLAGS) $(LINKFORSHARED) -o $@ Programs/python.o $(BLDLIBRARY) $(LIBS) $(MODLIBS) $(SYSLIBS)
 
 platform: $(BUILDPYTHON) pybuilddir.txt
 	$(RUNSHARED) $(PYTHON_FOR_BUILD) -c 'import sys ; from sysconfig import get_platform ; print("%s-%d.%d" % (get_platform(), *sys.version_info[:2]))' >platform
@@ -632,7 +639,7 @@
 	$(BLDSHARED) $(NO_AS_NEEDED) -o $@ -Wl,-h$@ $^
 
 libpython$(LDVERSION).dylib: $(LIBRARY_OBJS)
-	 $(CC) -dynamiclib -Wl,-single_module $(PY_LDFLAGS) -undefined dynamic_lookup -Wl,-install_name,$(prefix)/lib/libpython$(LDVERSION).dylib -Wl,-compatibility_version,$(VERSION) -Wl,-current_version,$(VERSION) -o $@ $(LIBRARY_OBJS) $(SHLIBS) $(LIBC) $(LIBM); \
+	 $(CC) -dynamiclib -Wl,-single_module $(PY_CORE_LDFLAGS) -undefined dynamic_lookup -Wl,-install_name,$(prefix)/lib/libpython$(LDVERSION).dylib -Wl,-compatibility_version,$(VERSION) -Wl,-current_version,$(VERSION) -o $@ $(LIBRARY_OBJS) $(SHLIBS) $(LIBC) $(LIBM); \
 
 
 libpython$(VERSION).sl: $(LIBRARY_OBJS)
@@ -657,7 +664,7 @@
 		$(LIBRARY) \
 		$(RESSRCDIR)/Info.plist
 	$(INSTALL) -d -m $(DIRMODE) $(PYTHONFRAMEWORKDIR)/Versions/$(VERSION)
-	$(CC) -o $(LDLIBRARY) $(PY_LDFLAGS) -dynamiclib \
+	$(CC) -o $(LDLIBRARY) $(PY_CORE_LDFLAGS) -dynamiclib \
 		-all_load $(LIBRARY) -Wl,-single_module \
 		-install_name $(DESTDIR)$(PYTHONFRAMEWORKINSTALLDIR)/Versions/$(VERSION)/$(PYTHONFRAMEWORK) \
 		-compatibility_version $(VERSION) \
@@ -698,7 +705,7 @@
 
 
 Programs/_testembed: Programs/_testembed.o $(LIBRARY) $(LDLIBRARY) $(PY3LIBRARY)
-	$(LINKCC) $(PY_LDFLAGS) $(LINKFORSHARED) -o $@ Programs/_testembed.o $(BLDLIBRARY) $(LIBS) $(MODLIBS) $(SYSLIBS)
+	$(LINKCC) $(PY_CORE_LDFLAGS) $(LINKFORSHARED) -o $@ Programs/_testembed.o $(BLDLIBRARY) $(LIBS) $(MODLIBS) $(SYSLIBS)
 
 ############################################################################
 # Importlib
@@ -706,7 +713,7 @@
 Programs/_freeze_importlib.o: Programs/_freeze_importlib.c Makefile
 
 Programs/_freeze_importlib: Programs/_freeze_importlib.o $(LIBRARY_OBJS_OMIT_FROZEN)
-	$(LINKCC) $(PY_LDFLAGS) -o $@ Programs/_freeze_importlib.o $(LIBRARY_OBJS_OMIT_FROZEN) $(LIBS) $(MODLIBS) $(SYSLIBS)
+	$(LINKCC) $(PY_CORE_LDFLAGS) -o $@ Programs/_freeze_importlib.o $(LIBRARY_OBJS_OMIT_FROZEN) $(LIBS) $(MODLIBS) $(SYSLIBS)
 
 .PHONY: regen-importlib
 regen-importlib: Programs/_freeze_importlib
@@ -794,7 +801,7 @@
 $(IO_OBJS): $(IO_H)
 
 $(PGEN): $(PGENOBJS)
-		$(CC) $(OPT) $(PY_LDFLAGS) $(PGENOBJS) $(LIBS) -o $(PGEN)
+		$(CC) $(OPT) $(PY_CORE_LDFLAGS) $(PGENOBJS) $(LIBS) -o $(PGEN)
 
 .PHONY: regen-grammar
 regen-grammar: $(PGEN)
diff --git a/Misc/NEWS.d/next/Build/2018-12-05-22-28-40.bpo-35257.dmcd_s.rst b/Misc/NEWS.d/next/Build/2018-12-05-22-28-40.bpo-35257.dmcd_s.rst
new file mode 100644
index 0000000..fad2525
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2018-12-05-22-28-40.bpo-35257.dmcd_s.rst
@@ -0,0 +1,2 @@
+Avoid leaking the linker flags from Link Time Optimizations (LTO)
+into distutils when compiling C extensions.
\ No newline at end of file
diff --git a/configure b/configure
index 8d33363..edb85b5 100755
--- a/configure
+++ b/configure
@@ -666,6 +666,7 @@
 LIBTOOL_CRUFT
 OTHER_LIBTOOL_OPT
 UNIVERSAL_ARCH_FLAGS
+LDFLAGS_NODIST
 CFLAGS_NODIST
 BASECFLAGS
 CFLAGS_ALIASING
@@ -6627,7 +6628,7 @@
   fi
 
   CFLAGS_NODIST="$CFLAGS_NODIST $LTOFLAGS"
-  LDFLAGS="$LDFLAGS $LTOFLAGS"
+  LDFLAGS_NODIST="$LDFLAGS_NODIST $LTOFLAGS"
 fi
 
 # Enable PGO flags.
@@ -6879,6 +6880,7 @@
 
 
 
+
 # The -arch flags for universal builds on OSX
 UNIVERSAL_ARCH_FLAGS=
 
diff --git a/configure.ac b/configure.ac
index 5c1c021..349c927 100644
--- a/configure.ac
+++ b/configure.ac
@@ -1358,7 +1358,7 @@
   fi
 
   CFLAGS_NODIST="$CFLAGS_NODIST $LTOFLAGS"
-  LDFLAGS="$LDFLAGS $LTOFLAGS"
+  LDFLAGS_NODIST="$LDFLAGS_NODIST $LTOFLAGS"
 fi
 
 # Enable PGO flags.
@@ -1518,6 +1518,7 @@
 
 AC_SUBST(BASECFLAGS)
 AC_SUBST(CFLAGS_NODIST)
+AC_SUBST(LDFLAGS_NODIST)
 
 # The -arch flags for universal builds on OSX
 UNIVERSAL_ARCH_FLAGS=
diff --git a/setup.py b/setup.py
index b87d05d..44a563b 100644
--- a/setup.py
+++ b/setup.py
@@ -18,11 +18,16 @@
 
 cross_compiling = "_PYTHON_HOST_PLATFORM" in os.environ
 
-# Add special CFLAGS reserved for building the interpreter and the stdlib
-# modules (Issue #21121).
-cflags = sysconfig.get_config_var('CFLAGS')
-py_cflags_nodist = sysconfig.get_config_var('PY_CFLAGS_NODIST')
-sysconfig.get_config_vars()['CFLAGS'] = cflags + ' ' + py_cflags_nodist
+# Set common compiler and linker flags derived from the Makefile,
+# reserved for building the interpreter and the stdlib modules.
+# See bpo-21121 and bpo-35257
+def set_compiler_flags(compiler_flags, compiler_py_flags_nodist):
+    flags = sysconfig.get_config_var(compiler_flags)
+    py_flags_nodist = sysconfig.get_config_var(compiler_py_flags_nodist)
+    sysconfig.get_config_vars()[compiler_flags] = flags + ' ' + py_flags_nodist
+
+set_compiler_flags('CFLAGS', 'PY_CFLAGS_NODIST')
+set_compiler_flags('LDFLAGS', 'PY_LDFLAGS_NODIST')
 
 class Dummy:
     """Hack for parallel build"""