diff --git a/Lib/test/test_site.py b/Lib/test/test_site.py
index 8168d7e..4d36e17 100644
--- a/Lib/test/test_site.py
+++ b/Lib/test/test_site.py
@@ -24,7 +24,7 @@
 else:
     raise unittest.SkipTest("importation of site.py suppressed")
 
-if not os.path.isdir(site.USER_SITE):
+if site.ENABLE_USER_SITE and not os.path.isdir(site.USER_SITE):
     # need to add user site directory for tests
     os.makedirs(site.USER_SITE)
     site.addsitedir(site.USER_SITE)
@@ -157,6 +157,8 @@
         finally:
             pth_file.cleanup()
 
+    @unittest.skipUnless(site.ENABLE_USER_SITE, "requires access to PEP 370 "
+                          "user-site (site.ENABLE_USER_SITE)")
     def test_s_option(self):
         usersite = site.USER_SITE
         self.assertIn(usersite, sys.path)
diff --git a/Misc/NEWS b/Misc/NEWS
index 1447ce3..94f22fc 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -1523,6 +1523,9 @@
 Tests
 -----
 
+- Issue #13304: Skip test case if user site-packages disabled (-s or
+  PYTHONNOUSERSITE).  (Patch by Carl Meyer)
+
 - Issue #5661: Add a test for ECONNRESET/EPIPE handling to test_asyncore. Patch
   by Xavier de Gaye.