diff --git a/Makefile.pre.in b/Makefile.pre.in
index 369b330..d30e565 100644
--- a/Makefile.pre.in
+++ b/Makefile.pre.in
@@ -789,7 +789,7 @@
 
 $(IO_OBJS): $(IO_H)
 
-$(GRAMMAR_H): $(GRAMMAR_INPUT) $(PGEN)
+$(GRAMMAR_H): $(GRAMMAR_INPUT) @PGEN_DEPENDENCY@
 	@$(MKDIR_P) Include
 	# Avoid copying the file onto itself for an in-tree build
 	if test "$(cross_compiling)" != "yes"; then \
diff --git a/Misc/ACKS b/Misc/ACKS
index 2b32fb8..a4a4cdc 100644
--- a/Misc/ACKS
+++ b/Misc/ACKS
@@ -1120,6 +1120,7 @@
 Bo Peng
 Santiago Peresón
 George Peristerakis
+Thomas Perl
 Mathieu Perreault
 Mark Perrego
 Trevor Perrin
diff --git a/Misc/NEWS b/Misc/NEWS
index 3ac2ed3..799e1f0 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -145,6 +145,9 @@
 Build
 -----
 
+- Issue #27490: Do not build pgen when cross-compiling.  Patch by Thomas
+  Perl.
+
 - Issue #26662: Set PYTHON_FOR_GEN in configure as the Python program to be
   used for file generation during the build.
 
diff --git a/configure b/configure
index 550c1bb..f0cf515 100755
--- a/configure
+++ b/configure
@@ -739,6 +739,7 @@
 CONFIG_ARGS
 SOVERSION
 VERSION
+PGEN_DEPENDENCY
 PYTHON_FOR_BUILD
 PYTHON_FOR_GEN
 host_os
@@ -3049,14 +3050,17 @@
 $as_echo "$interp" >&6; }
 	PYTHON_FOR_BUILD='_PYTHON_PROJECT_BASE=$(abs_builddir) _PYTHON_HOST_PLATFORM=$(_PYTHON_HOST_PLATFORM) PYTHONPATH=$(shell test -f pybuilddir.txt && echo $(abs_builddir)/`cat pybuilddir.txt`:)$(srcdir)/Lib:$(srcdir)/Lib/$(PLATDIR) '$interp
     fi
+    PGEN_DEPENDENCY=''
 elif test "$cross_compiling" = maybe; then
     as_fn_error $? "Cross compiling required --host=HOST-TUPLE and --build=ARCH" "$LINENO" 5
 else
     PYTHON_FOR_BUILD='./$(BUILDPYTHON) -E'
+    PGEN_DEPENDENCY='$(PGEN)'
 fi
 
 
 
+
 if test "$prefix" != "/"; then
     prefix=`echo "$prefix" | sed -e 's/\/$//g'`
 fi
diff --git a/configure.ac b/configure.ac
index bf27ab8..bf2a348 100644
--- a/configure.ac
+++ b/configure.ac
@@ -81,12 +81,15 @@
         AC_MSG_RESULT($interp)
 	PYTHON_FOR_BUILD='_PYTHON_PROJECT_BASE=$(abs_builddir) _PYTHON_HOST_PLATFORM=$(_PYTHON_HOST_PLATFORM) PYTHONPATH=$(shell test -f pybuilddir.txt && echo $(abs_builddir)/`cat pybuilddir.txt`:)$(srcdir)/Lib:$(srcdir)/Lib/$(PLATDIR) '$interp
     fi
+    PGEN_DEPENDENCY=''
 elif test "$cross_compiling" = maybe; then
     AC_MSG_ERROR([Cross compiling required --host=HOST-TUPLE and --build=ARCH])
 else
     PYTHON_FOR_BUILD='./$(BUILDPYTHON) -E'
+    PGEN_DEPENDENCY='$(PGEN)'
 fi
 AC_SUBST(PYTHON_FOR_BUILD)
+AC_SUBST(PGEN_DEPENDENCY)
 
 dnl Ensure that if prefix is specified, it does not end in a slash. If
 dnl it does, we get path names containing '//' which is both ugly and