diff --git a/src/_cffi_src/openssl/ssl.py b/src/_cffi_src/openssl/ssl.py
index db884b3..7565df1 100644
--- a/src/_cffi_src/openssl/ssl.py
+++ b/src/_cffi_src/openssl/ssl.py
@@ -25,6 +25,7 @@
 static const long Cryptography_HAS_GET_SERVER_TMP_KEY;
 static const long Cryptography_HAS_SSL_CTX_SET_CLIENT_CERT_ENGINE;
 static const long Cryptography_HAS_SSL_CTX_CLEAR_OPTIONS;
+static const long Cryptography_HAS_NPN_NEGOTIATED;
 
 /* Internally invented symbol to tell us if SNI is supported */
 static const long Cryptography_HAS_TLSEXT_HOSTNAME;
@@ -130,6 +131,8 @@
 static const long TLS_ST_BEFORE;
 static const long TLS_ST_OK;
 
+static const long OPENSSL_NPN_NEGOTIATED;
+
 typedef ... SSL_METHOD;
 typedef ... SSL_CTX;
 
@@ -703,4 +706,13 @@
 static const long TLS_ST_BEFORE = 0;
 static const long TLS_ST_OK = 0;
 #endif
+
+/* This define is available in 1.0.1+ so we can remove this when we drop
+   support for 1.0.0 */
+#ifdef OPENSSL_NPN_NEGOTIATED
+static const long Cryptography_HAS_NPN_NEGOTIATED = 1;
+#else
+static const long OPENSSL_NPN_NEGOTIATED = -1;
+static const long Cryptography_HAS_NPN_NEGOTIATED = 0;
+#endif
 """
diff --git a/src/cryptography/hazmat/bindings/openssl/_conditional.py b/src/cryptography/hazmat/bindings/openssl/_conditional.py
index 02032a0..d1cebd8 100644
--- a/src/cryptography/hazmat/bindings/openssl/_conditional.py
+++ b/src/cryptography/hazmat/bindings/openssl/_conditional.py
@@ -318,5 +318,8 @@
     ],
     "Cryptography_HAS_SCRYPT": [
         "EVP_PBE_scrypt",
-    ]
+    ],
+    "Cryptography_HAS_NPN_NEGOTIATED": [
+        "OPENSSL_NPN_NEGOTIATED",
+    ],
 }