diff --git a/.github/.OwlBot.lock.yaml b/.github/.OwlBot.lock.yaml
index ee94722..7d98291 100644
--- a/.github/.OwlBot.lock.yaml
+++ b/.github/.OwlBot.lock.yaml
@@ -1,3 +1,3 @@
 docker:
   image: gcr.io/cloud-devrel-public-resources/owlbot-python:latest
-  digest: sha256:6e7328583be8edd3ba8f35311c76a1ecbc823010279ccb6ab46b7a76e25eafcc
+  digest: sha256:58f73ba196b5414782605236dd0712a73541b44ff2ff4d3a36ec41092dd6fa5b
diff --git a/.kokoro/samples/python3.10/common.cfg b/.kokoro/samples/python3.10/common.cfg
new file mode 100644
index 0000000..b1a684c
--- /dev/null
+++ b/.kokoro/samples/python3.10/common.cfg
@@ -0,0 +1,40 @@
+# Format: //devtools/kokoro/config/proto/build.proto
+
+# Build logs will be here
+action {
+  define_artifacts {
+    regex: "**/*sponge_log.xml"
+  }
+}
+
+# Specify which tests to run
+env_vars: {
+    key: "RUN_TESTS_SESSION"
+    value: "py-3.10"
+}
+
+# Declare build specific Cloud project.
+env_vars: {
+    key: "BUILD_SPECIFIC_GCLOUD_PROJECT"
+    value: "python-docs-samples-tests-310"
+}
+
+env_vars: {
+    key: "TRAMPOLINE_BUILD_FILE"
+    value: "github/google-api-python-client/.kokoro/test-samples.sh"
+}
+
+# Configure the docker image for kokoro-trampoline.
+env_vars: {
+    key: "TRAMPOLINE_IMAGE"
+    value: "gcr.io/cloud-devrel-kokoro-resources/python-samples-testing-docker"
+}
+
+# Download secrets for samples
+gfile_resources: "/bigstore/cloud-devrel-kokoro-resources/python-docs-samples"
+
+# Download trampoline resources.
+gfile_resources: "/bigstore/cloud-devrel-kokoro-resources/trampoline"
+
+# Use the trampoline script to run in docker.
+build_file: "google-api-python-client/.kokoro/trampoline_v2.sh"
\ No newline at end of file
diff --git a/.kokoro/samples/python3.10/continuous.cfg b/.kokoro/samples/python3.10/continuous.cfg
new file mode 100644
index 0000000..a1c8d97
--- /dev/null
+++ b/.kokoro/samples/python3.10/continuous.cfg
@@ -0,0 +1,6 @@
+# Format: //devtools/kokoro/config/proto/build.proto
+
+env_vars: {
+    key: "INSTALL_LIBRARY_FROM_SOURCE"
+    value: "True"
+}
\ No newline at end of file
diff --git a/.kokoro/samples/python3.10/periodic-head.cfg b/.kokoro/samples/python3.10/periodic-head.cfg
new file mode 100644
index 0000000..fff273b
--- /dev/null
+++ b/.kokoro/samples/python3.10/periodic-head.cfg
@@ -0,0 +1,11 @@
+# Format: //devtools/kokoro/config/proto/build.proto
+
+env_vars: {
+    key: "INSTALL_LIBRARY_FROM_SOURCE"
+    value: "True"
+}
+
+env_vars: {
+    key: "TRAMPOLINE_BUILD_FILE"
+    value: "github/google-api-python-client/.kokoro/test-samples-against-head.sh"
+}
diff --git a/.kokoro/samples/python3.10/periodic.cfg b/.kokoro/samples/python3.10/periodic.cfg
new file mode 100644
index 0000000..71cd1e5
--- /dev/null
+++ b/.kokoro/samples/python3.10/periodic.cfg
@@ -0,0 +1,6 @@
+# Format: //devtools/kokoro/config/proto/build.proto
+
+env_vars: {
+    key: "INSTALL_LIBRARY_FROM_SOURCE"
+    value: "False"
+}
diff --git a/.kokoro/samples/python3.10/presubmit.cfg b/.kokoro/samples/python3.10/presubmit.cfg
new file mode 100644
index 0000000..a1c8d97
--- /dev/null
+++ b/.kokoro/samples/python3.10/presubmit.cfg
@@ -0,0 +1,6 @@
+# Format: //devtools/kokoro/config/proto/build.proto
+
+env_vars: {
+    key: "INSTALL_LIBRARY_FROM_SOURCE"
+    value: "True"
+}
\ No newline at end of file
diff --git a/samples/compute/noxfile.py b/samples/compute/noxfile.py
index 1fd8956..93a9122 100644
--- a/samples/compute/noxfile.py
+++ b/samples/compute/noxfile.py
@@ -87,7 +87,7 @@
 
 # DO NOT EDIT - automatically generated.
 # All versions used to test samples.
-ALL_VERSIONS = ["3.6", "3.7", "3.8", "3.9"]
+ALL_VERSIONS = ["3.6", "3.7", "3.8", "3.9", "3.10"]
 
 # Any default versions that should be ignored.
 IGNORED_VERSIONS = TEST_CONFIG["ignored_versions"]