diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index ab28dcb..0d8765f 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -26,6 +26,8 @@
 
 - ``OpenSSL.SSL.Connection`` now sets ``SSL_MODE_AUTO_RETRY`` by default.
   `#753 <https://github.com/pyca/pyopenssl/pull/753>`_
+- Added ``Context.set_tlsext_use_srtp`` to enable negotiation of SRTP keying material.
+  `#734 <https://github.com/pyca/pyopenssl/pull/734>`_
 
 
 ----
diff --git a/src/OpenSSL/SSL.py b/src/OpenSSL/SSL.py
index 1bf6450..8d8cfe3 100644
--- a/src/OpenSSL/SSL.py
+++ b/src/OpenSSL/SSL.py
@@ -1371,6 +1371,21 @@
         _lib.SSL_CTX_set_tlsext_servername_callback(
             self._context, self._tlsext_servername_callback)
 
+    def set_tlsext_use_srtp(self, profiles):
+        """
+        Enable support for negotiating SRTP keying material.
+
+        :param bytes profiles: A colon delimited list of protection profile
+            names, like ``b'SRTP_AES128_CM_SHA1_80:SRTP_AES128_CM_SHA1_32'``.
+        :return: None
+        """
+        if not isinstance(profiles, bytes):
+            raise TypeError("profiles must be a byte string.")
+
+        _openssl_assert(
+            _lib.SSL_CTX_set_tlsext_use_srtp(self._context, profiles) == 0
+        )
+
     @_requires_npn
     def set_npn_advertise_callback(self, callback):
         """
diff --git a/tests/test_ssl.py b/tests/test_ssl.py
index 87bd18c..b09fce7 100644
--- a/tests/test_ssl.py
+++ b/tests/test_ssl.py
@@ -1593,6 +1593,35 @@
         store = context.get_cert_store()
         assert isinstance(store, X509Store)
 
+    def test_set_tlsext_use_srtp_not_bytes(self):
+        """
+        `Context.set_tlsext_use_srtp' enables negotiating SRTP keying material.
+
+        It raises a TypeError if the list of profiles is not a byte string.
+        """
+        context = Context(TLSv1_METHOD)
+        with pytest.raises(TypeError):
+            context.set_tlsext_use_srtp(text_type('SRTP_AES128_CM_SHA1_80'))
+
+    def test_set_tlsext_use_srtp_invalid_profile(self):
+        """
+        `Context.set_tlsext_use_srtp' enables negotiating SRTP keying material.
+
+        It raises an Error if the call to OpenSSL fails.
+        """
+        context = Context(TLSv1_METHOD)
+        with pytest.raises(Error):
+            context.set_tlsext_use_srtp(b'SRTP_BOGUS')
+
+    def test_set_tlsext_use_srtp_valid(self):
+        """
+        `Context.set_tlsext_use_srtp' enables negotiating SRTP keying material.
+
+        It does not return anything.
+        """
+        context = Context(TLSv1_METHOD)
+        assert context.set_tlsext_use_srtp(b'SRTP_AES128_CM_SHA1_80') is None
+
 
 class TestServerNameCallback(object):
     """